1,184 Results for : instance

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    Biomedical Informatics for Cancer Research
    view, showing that multiple molecular pathways must be affected for cancer to develop, but with different specific proteins in each pathway mutated or differentially expressed in a given tumor (The Cancer Genome Atlas Research Network 2008; Parsons et al. 2008). Different studies demonstrated that while widespread mutations exist in cancer, not all mutations drive cancer development (Lin et al. 2007). This suggests a need to target only a deleterious subset of aberrant proteins, since any tre- ment must aim to improve health to justify its potential side effects. Treatment for cancer must become highly individualized, focusing on the specific aberrant driver proteins in an individual. This drives a need for informatics in cancer far beyond the need in other diseases. For instance, routine treatment with statins has become widespread for minimizing heart disease, with most patients responding to standard doses (Wilt et al. 2004). In contrast, standard treatment for cancer must become tailored to the molecular phenotype of an individual tumor, with each patient receiving a different combination of therapeutics aimed at the specific aberrant proteins driving the cancer. Tracking the aberrations that drive cancers, identifying biomarkers unique to each individual for molecular-level di- nosis and treatment response, monitoring adverse events and complex dosing schedules, and providing annotated molecular data for ongoing research to improve treatments comprise a major biomedical informatics need.
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    • Price: 70.99 EUR excl. shipping
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    Blank Pages and Other Stories
    The extraordinary new story collection from one of Ireland's greatest writers and bestselling author of Mindwinter Break.Bernard MacLaverty is a consummately gifted short-story writer and novelist whose work - like that of John McGahern, William Trevor, Edna O'Brien or Colm Tóibín - is deceptively simple on the surface, but carries a turbulent undertow. Everywhere, the dark currents of violence, persecution and regret pull at his subject matter: family love, the making of art, Catholicism, the Troubles and, latterly, ageing.Blank Pages is a collection of twelve extraordinary new stories that show the emotional range of a master. 'Blackthorns', for instance, tells of a poor out-of-work Catholic man who falls gravely ill in the sectarian Northern Ireland of 1942 but is brought back from the brink by an unlikely saviour. The most recently written story here is the harrowing but transcendent 'The End of Days', which imagines the last moments in the life of painter Egon Schiele, watching his wife dying of Spanish flu - the world's worst pandemic, until now.Much of what MacLaverty writes is an amalgam of sadness and joy, of circumlocution and directness. He never wastes words but neither does he ever forget to make them sing. Each story he writes creates a universe.'Can we just accept that Bernard MacLaverty is one of the greats now?' Herald
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    • Price: 12.99 EUR excl. shipping
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    Putin's Postbox (eBook, ePUB)
    Eight essays on literature, language, art, Europe and life from one of Germany's most revered living writers. After a visit to Putin's old postbox, the reader is taken to Dresden and Brixton, Gdansk and Minsk, diverted to birds, bees, stray cats and pet dogs, confronted with Stasi and KGB, Proust and Jah Shaka, puzzled by overcoats and anoraks, Francis Bacon and Vermeer, and lost (then found) in service stations and memorial centres. Throughout, Marcel Beyer forges unexpected links and makes unpredictable leaps. "I work from the margins, partly very literally as I build my sentences, for instance when I start with the name of a colour rather than a noun, to explore how the sentence might be steered from there to a subject. In my reading, I am drawn to the outliers or, as malicious claims would have it, to the obscure. Central books: that is, those everyone can agree on, have never much interested me. I am rarely tempted to explore the centre of my world in writing, and even if I did want to encroach upon a centre, I would have to choose a path from the outside. But outside, too, one advances to the heart of things." Inspired by the great W. G. Sebald, Beyer's playful literary investigations wend through the high points and horrors of Europe's artistic history, towards a profoundly personal conclusion.
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    • Price: 6.49 EUR excl. shipping
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    Silver Borne (eBook, ePUB)
    The fifth novel in the international No. 1 bestselling Mercy Thompson series - the major urban fantasy hit of the decade'I love these books!' Charlaine Harris'The best new fantasy series I've read in years' Kelley ArmstrongMERCY THOMPSON: MECHANIC, SHAPESHIFTER, FIGHTERBeing a mechanic is hard work. Mercy Thompson, for instance, just spent the last couple of months trying to evade the murderous queen of the local vampire seethe, and now the leader of the werewolf pack - who's maybe-more-than-just-a-friend - has asked for her help. A book of fae secrets has come to light and they're all about to find out how implacable - and dangerous - the fae can be.OK, so maybe her troubles have nothing to do with the job. But she sure could use a holiday . . .A fast-paced adventure featuring the ingenious and appealing Mercy Thompson - mechanic, trouble-magnet and coyote shapechanger.Praise for the series:'Plenty of twists and turns . . . Kept me entertained from its deceptively innocent beginning to its can't-put-it-down end' Kim Harrison, bestselling author of Dead Witch Walking 'I enjoyed every minute of it. I love Mercy and can't wait for her to kick some more ass' Lilith Saintcrow Books by Patricia Briggs:The Mercy Thompson booksMoon CalledBlood BoundIron KissedBone CrossedSilver BorneRiver MarkedFrost BurnedNight BrokenFire TouchedSilence FallenStorm CursedShifting Shadows (Stories from the world of Mercy Thompson)
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    • Price: 2.99 EUR excl. shipping
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    Symbolic Logic (eBook, PDF)
    This book provides a comprehensive introduction to the essential elements of standard (classical) symbolic logic. Key topics covered include: · The characteristic nature and scope of logic as a discipline · The construction of a series of distinctly named formal languages suitable for formal translation · Semantic models · The construction of decision procedures · The execution of proof-theoretic arrangements like natural deduction and proof-sequent systems The book covers both the semantics and proof theory of the standard sentential (propositional) logic and predicate (first-order) logic. Other topics covered include: parsing trees, extraction of alternative notations (for instance, Polish notation), Fitch-style proof-theory, sequent and 'tree' proof systems, comparisons and contrasts with intuitionistic logic, and presentations of predicate logic models. An ancillary chapter on elements of set theory is conveniently placed at the end and includes insights into the Zermelo-Fraenkel systematization of set theory. The philosophy of logic is also explored. Exercises in the text provide instruction on mathematical induction for the construction of formula, tests for the well-formedness of Polish notation, and functional completeness. Symbolic Logic is essential reading for all philosophy students taking intermediate level formal logic courses and will also appeal to diligent first year students of logic. The text is replete with exercises on both the formal machinery and the philosophical aspects of logic.
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    • Price: 40.95 EUR excl. shipping
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    Everything Has Teeth , Hörbuch, Digital, ungekürzt, 496min
    Contains the Splatterpunk Award-winning story The Tipping Point.A city where people are turning gleefully insane. Inescapable blood-sucking bugs. A serial killer who may have discovered proof of alien life. A kinky proposal to "even out" an instance of infidelity. A man whose fingernails are growing at an out of control rate. Twisted new spins on the legends of John Henry and Humpty Dumpty. The all-time worst bathtub in which to bathe a child. The inconvenience of finding a dead Bigfoot in your yard.These are only a few of the stories in Jeff Strand's deranged new collection, which includes several macabre tales written just for these bloody audiobook.Table of contents:The Tipping PointNailsStumpsJohn Henry, The Steel Drivin' ManFair TradeChiggersCryThe Fierce Stabbing and Subsequent Post-Death Vengeance of Scooter BrownIt's Bath Time!Alien FaceApocalypse of the Yard GnomeDead Bigfoot on the LawnGross-Out: The ReturnDeformed SonThe Origin of SlashySecret Message (Decoded)The Sentient Cherry Cola That Tried to Destroy the WorldThe Eggman FallethThe Story of My First KissDad (A True Story)Bad Bratwurst ungekürzt. Language: English. Narrator: Andy Barker. Audio sample: https://samples.audible.de/bk/acx0/172336/bk_acx0_172336_sample.mp3. Digital audiobook in aax.
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    • Price: 9.95 EUR excl. shipping
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    The Fermata , Hörbuch, Digital, ungekürzt, 647min
    The Fermata is the most risky of Nicholson Baker's emotional histories. His narrator, Arno Strine, is a 35-year-old office temp who is writing his autobiography. "It's harder than I thought!" he admits. His "Fold-powers" are easier; he can stop the world and use it as his own pleasure ground. Arno uses this gift not for evil or material gain (he would feel guilty about stealing), though he does undress a good number of women and momentarily place them in compromising positions - always, in his view, with respect and love. Anyone who can stop time and refer in self-delight to his "chronanisms" can't be all bad! Like Baker's other books, The Fermata gains little from synopsis. The pleasure is literally in the text. What's memorable is less the sex and the sex toys (including the "Monasticon," in the shape of a monk holding a vibrating manuscript) than Arno's wistful recollections of intimacy: the noise, for instance, of his ex-girlfriend's nail clipper, "which I listened to in bed as some listen to real birdsong." ungekürzt. Language: English. Narrator: Peter Ganim. Audio sample: https://samples.audible.de/bk/adbl/003443/bk_adbl_003443_sample.mp3. Digital audiobook in aax.
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    • Price: 9.95 EUR excl. shipping
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    Eastern Asian Classics: The Art of War, Tao Te Ching, and The Book of Five Rings , Hörbuch, Digital, ungekürzt, 229min
    These three classic Eastern Asian works have stood the test of time, having been listen all across the world to this day. The Art of War is an ancient Chinese military treatise authored by military strategist Sun Tzu. The work is comprised of 13 chapters, each chapter is devoted to a distinct aspect of warfare relating to military strategy. The Art of War has had a profound influence on both Eastern and Western military thinking, business tactics, and strategy. The Tao Te Ching is a fundamental text for both philosophical and religious Taoism. Its influence has spread widely outside East Asia and it is among the most translated works in world literature. The Book of Five Rings is an audiobook on the martial arts in general, written by the Japanese swordsman Miyamoto Musashi around 1645. It enjoys an audience considerably broader than only that of martial artists and people across East Asia: for instance, some foreign business leaders find its discussion of conflict and taking the advantage to be relevant to their work in a business context. ungekürzt. Language: English. Narrator: Gregg Rizzo. Audio sample: https://samples.audible.de/bk/acx0/141088/bk_acx0_141088_sample.mp3. Digital audiobook in aax.
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    • Price: 9.95 EUR excl. shipping
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    1966: My World Cup Story , Hörbuch, Digital, ungekürzt, 533min
    In 1966 England won the World Cup at Wembley. Sir Bobby Charlton, England's greatest ever player, was there on the pitch. Now, 50 years on, Sir Bobby looks back on the most glorious moment of his life and England's greatest sporting achievement. In 1966 he takes us through the buildup to the tournament and to the final itself, describing what he saw, what he heard, and what he felt. He explains what it was like to be part of Sir Alf Ramsey's team and gives us his personal memories of his teammates, the matches, the atmosphere, the emotion of being carried on the wave of a nation's euphoria and how it felt to go toe-to-toe with some of the foremost footballers to ever play the game. He reveals what it means to be forever defined by one moment - how a life fully lived can come back to one single instance, one day when a man stands side by side with his best friends, united in a single aim, in front of a watching nation. ungekürzt. Language: English. Narrator: Bernard Hill. Audio sample: https://samples.audible.de/bk/rhuk/002423/bk_rhuk_002423_sample.mp3. Digital audiobook in aax.
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    • Price: 9.95 EUR excl. shipping
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    Million Dollars Mind: Millionaire Fast Lane: A Rich Mind Makes Money , Hörbuch, Digital, ungekürzt, 162min
    There's an interesting and obvious power in knowing, getting to be, and being your genuine self. The people who are really upbeat in life comprehend this power and eagerly adhere to their authentic selves. To be authentic isn't to enable a circumstance or individual to transform you, except if to improve things. Individual authenticity is immovably set up, paying little respect to who is in your organization. Without a doubt, your style of correspondence and how you present yourself (for example, formal or casual discourse) may change, yet not your genuine center. There is, without a doubt, an authenticity issue in the public eye, the same number of you have likely observed and experienced. For instance, one study found that almost 50 percent surprisingly feel they have to "counterfeit it" at work (a conviction that alone adds to an effectively unpleasant workplace). When we stroll into a position of business to buy something, it's typical to encounter a feeling of uncertainty about the individual doing the selling. "How might this benefit them?"" ungekürzt. Language: English. Narrator: Chris Adkins. Audio sample: https://samples.audible.de/bk/acx0/188695/bk_acx0_188695_sample.mp3. Digital audiobook in aax.
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    • Price: 9.95 EUR excl. shipping

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